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This track will feature presentations from leading investigators around the globe about their research and discoveries translating into new therapies against various diseases and the latest developments in translational medicine. The areas covered in this track include topics such as the discovery and validation of potential targets using microarray, RNAi and other genomic approaches; gene and cell based therapies and advances in pre-clinical and clinical research.

  • Discovery platforms
  • Target identification and validation
  • Screening and imaging platforms
  • Biomarker research
  • Biologics, biosimilars and immunogenicity
  • Vaccine biology
  • Cell based therapies
  • RNAi and microRNAs
  • Microarrays
  • Toxicogenomics
  • Disease genomics
  • Pharmacogenomics and personalized medicine
  • Clinical research and clinical trials

TRACK SCHEDULE

Aug 12 @ 9:12 am – 9:17 am
Introducing the Track, Genomics and Translational Medicine @ Acharya Hall | Vallikavu | Kerala | India
Dr. Bipin Nair, Dean-Biotechnology, Amrita University
Plenary Address, Novel drug targets and novel drugs using proteomics technology @ Acharya Hall | Vallikavu | Kerala | India
Sudhir Sahasrabudhe, Ph.D. CEO, Rines Therapeutics Research Professor of Medicinal Chemistry, University of Utah, USA NOVEL DRUG TARGETS AND NOVEL DRUGS USING PROTEOMICS TECHNOLOGY Translational medicine is the conversion of scientific discovery into improvement of human health. The key to
Invited Talk: A model to accelerate translation of academic discoveries into industry-ready technologies @ Acharya Hall | Vallikavu | Kerala | India
Taslimarif Saiyed. Ph.D Chief Operating Officer, C-CAMP, NCBS, Bengaluru, India    
Invited Talk: Managing the “Branch Manager”, Sprouty2, in Health and Disease @ Acharya Hall | Vallikavu | Kerala | India
Tarun B. Patel, Ph.D Professor and Chair of Pharmacology, Loyola University, Chicago, USA        
Aug 12 @ 11:42 am – 12:07 pm
Invited Talk: Osteoarthritis: diagnosis, treatment and challenges @ Acharya Hall | Vallikavu | Kerala | India
Hideaki Nagase, Ph.D. Kennedy Institute of Rheumatology-Centre for Degenerative Diseases, University of Oxford, UK Osteoarthritis: diagnosis, treatment and challenges Hideaki Nagase1, Ngee Han Lim1, George Bou-Gharios1, Ernst Meinjohanns2  and Morten Meldal3 Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology
Invited Talk: Epigenetic Changes due to DNA Methylation in Human Epithelial Tumors @ Acharya Hall | Vallikavu | Kerala | India
K. Satyamoorthy, Ph.D. Director, Life Sciences Centre, Manipal University, India Epigenetic Changes due to DNA Methylation in Human Epithelial Tumors Extensive global hypomethylation in the genome and hypermthylation of selective tumor specific suppressor genes appears to be a hallmark of
Plenary Address: A novel strategy for targeting metalloproteinases in cancer @ Acharya Hall | Vallikavu | Kerala | India
Gillian Murphy, Ph.D. Professor, Department of Oncology, University of Cambridge, UK A novel strategy for targeting metalloproteinases in cancer Epithelial tumours evolve in a multi-step manner, involving both inflammatory and mesenchymal cells. Although intrinsic factors drive malignant progression, the influence
Invited Talk: ColoAd1- An oncolytic adenovirus derived by directed evolution @ Acharya Hall | Vallikavu | Kerala | India
Terry Hermiston, Ph.D. Vice President, US Biologics Research Site Head, US Innovation Center Bayer Healthcare, USA ColoAd1 – An oncolytic adenovirus derived by directed evolution Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach
Invited Talk: Identification of Potential Early Diagnostic Biomarkers for Gliomas and Various Infectious Diseases using Proteomic Technologies @ Acharya Hall | Vallikavu | Kerala | India
Sanjeeva Srivastava, Ph.D. Assistant Professor, Proteomics Lab, IIT-Bombay, India Identification of Potential Early Diagnostic Biomarkers for Gliomas and Various Infectious Diseases using Proteomic Technologies  The spectacular advancements achieved in the field of proteomics research during the last decade have propelled
Delegate Talk: Genomic and Genetic Analyses of the Transcriptional Regulation of G1/S Genes by Genotoxic Stress @ Acharya Hall | Vallikavu | Kerala | India
Anna Travesa, Curt Wittenerg, Dwight Kuo, Robert A.M. de Bruin, Trey Ideker and Curt Wittenberg Genomic and Genetic Analyses of the Transcriptional Regulation of G1/S Genes by Genotoxic Stress  Anna Travesa1,4, Dwight Kuo2, Robert A.M. de Bruin3, Trey Ideker2, and Curt
Delegate Talk: Role of microRNAs in Developmental Megakaryocytopoiesis @ Acharya Hall | Vallikavu | Kerala | India
Ravi Gutti, Rambabu Undi, Ravinder Kandi and Itishri Sahu Hematologic Oncology, Stem Cells and Blood Disorders Laboratory, School of Life Sciences, Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad 500 046 (AP), India. e-mail: guttiravi@gmail.com Megakaryocytopoiesis is governed by a complex network
Delegate Talk:  AIB1 Mediated Modulation of CXCR4-SDF1 Signaling in Breast Cancer @ Acharya Hall | Vallikavu | Kerala | India
Binu K Aa, Jem Prabhakarb, Thara Sc and Lakshmi Sd,∗ aDepartment of Clinical Diagnostics Services and Translational Research, Malabar Cancer Centre, Thalassery, Kerala, India. bDivision of Surgical Oncology, Division of Pathology dDivision of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala,
Aug 13 @ 9:05 am – 9:16 am
Introducing the Track: Genomics and Translational Medicine @ Acharya Hall | Vallikavu | Kerala | India
Kartik Iyer Assistant Professor, School of Biotechnology, Amrita University
Plenary Address: Making sense of pathogen sensors of Innate Immunity: Utility of their ligands as antiviral agens and adjuvants for vaccines. @ Acharya Hall | Vallikavu | Kerala | India
Suryaprakash Sambhara, DVM, Ph.D Chief, Immunology Section, Influenza Division, CDC, Atlanta, USA Making sense of pathogen sensors of Innate Immunity: Utility of their ligands as antiviral agents and adjuvants for vaccines. Currently used antiviral agents act by inhibiting viral entry,
Aug 13 @ 10:22 am – 10:50 am
Invited Talk: Genomics of Restriction- Modification Systems @ Acharya Hall | Vallikavu | Kerala | India
D. Narasimha Rao, Ph.D. Professor, Dept of Biochemistry, Indian Institute of Science, Bangalore, India Genomics of Restriction-Modification Systems Restriction endonucleases occur ubiquitously among procaryotic organisms. Up to 1% of the genome of procaryotic organisms is taken up by the genes for these
Invited Talk: Interrogating Signaling Networks at the Single Cell Level in Primary Human Patient Samples @ Acharya Hall | Vallikavu | Kerala | India
Michelle Hermiston, MD, Ph.D. Assistant Professor, Department of Pediatrics University of California San Francisco, USA Interrogating Signaling Networks at the Single Cell Level In Primary Human Patient Samples Multiparameter phosphoflow cytometry is a highly sensitive proteomic approach that enables monitoring of
Invited Talk: “Inside-out” NF-kappa B signaling in cancer and other pathologies @ Acharya Hall | Vallikavu | Kerala | India
Shigeki Miyamoto, Ph.D. Professor, McArdle Laboratory for Cancer Research – UW Carbone Cancer Center Department of Oncology, School of Medicine and Public Health University of Wisconsin-Madison “Inside-out” NF-κB signaling in cancer and other pathologies The NF-κB/Rel family of transcription factors contributes to critical
Aug 13 @ 11:50 am – 12:12 pm
Invited Talk: Pertubation of DNA topology in mycobacteria @ Acharya Hall | Vallikavu | Kerala | India
V. Nagaraja Ph.D. Professor, Indian Institute of Science, Bengaluru, India Perturbation of DNA topology in mycobacteria To maintain the topological homeostasis of the genome in the cell, DNA topoisomerases catalyse DNA cleavage, strand passage and rejoining of the ends. Thus,
Invited Talk: Regulation of the MHC complex and HLA solubilisation by the Flavivirus, Japanese Encephalitis Virus @ Acharya Hall | Vallikavu | Kerala | India
R. Manjunath, Ph.D. Associate Professor, Dept of Biochemistry, Indian Institute of Science, Bengaluru, India REGULATION OF THE MHC COMPLEX AND HLA SOLUBILISATION BY THE FLAVIVIRUS, JAPANESE ENCEPHALITIS VIRUS Viral encephalitis caused by Japanese encephalitis virus (JEV) and West Nile Virus
Invited Talk: Gut microbiome and health- Moving towards the new era of translational medicine @ Acharya Hall | Vallikavu | Kerala | India
Sharmila Mande, Ph.D. Principal Scientist and Head, Bio Sciences R&D, TCS Innovation Labs, Pune Gut microbiome and health: Moving towards the new era of translational medicine The microbes inhabiting our body outnumber our own cells by a factor of 10.
Invited Talk: Targeting aberrant cancer kinome using rationally designed nano-polypharmaceutics @ Acharya Hall | Vallikavu | Kerala | India
Manzoor K, Ph.D. Professor, Centre for Nanoscience & Molecular Medicine, Amrita University Targeting aberrant cancer kinome using rationally designed nano-polypharmaceutics Manzoor Koyakutty, Archana Ratnakumary, Parwathy Chandran, Anusha Ashokan, and Shanti Nair `War on Cancer’ was declared nearly 40 years ago.
Invited Talk: The system of PAS proteins (HIF and AhR) as an interface between environment and skin homeostasis @ Acharya Hall | Vallikavu | Kerala | India
Andrey Panteleyev, Ph.D. Vice Chair, Division of Molecular Biology, NBICS Centre-Kurchatov Institute, Moscow, Russia The system of PAS proteins (HIF and AhR) as an interface between environment and skin homeostasis Regulation of normal skin functions as well as etiology of
Invited Talk: From Camels to Worms: Novel Approaches for Drug Discovery in Parkinson’s Disease. @ Acharya Hall | Vallikavu | Kerala | India
Tim Guilliams, Ph.D. Junior Associate Fellow at the Centre for Science and Policy, University of Cambridge From Camels to Worms: Novel Approaches for Drug Discovery in Parkinson’s Disease The discovery of novel treatments for neurodegenerative diseases, such as Parkinson’s disease,
Invited Talk: Probing Estrogen Receptor - Tumor Suppressor p53 Interaction in Cancer: From Basic Research to Clinical Trial @ Acharya Hall | Vallikavu | Kerala | India
Gokul Das, Ph.D. Co-Director, Breast Disease Site Research Group, Roswell Park Cancer Institute, Buffalo, NY Probing Estrogen Receptor−Tumor Suppressor p53 Interaction in Cancer: From Basic Research to Clinical Trial Tumor suppressor p53 and estrogen receptor have opposite roles in the
Aug 13 @ 4:25 pm – 5:04 pm
Invited Talk: Cancer Stem Cells – Target Colon Cancer @ Acharya Hall | Vallikavu | Kerala | India
Shrikant Anant, Ph.D. The Department of Molecular & Integrative Physiology, Kansas University Medical Center, USA Cancer Stem Cells: Target Colon Cancers Shrikant Anant, Deep Kwatra and Dharmalingam Subramaniam Colon cancer is a leading cause of cancer related deaths in the
Invited Talk: New paths for treatment of complex diseases: target combinatorial drug therapy @ Acharya Hall | Vallikavu | Kerala | India
Bodo Eickhoff, Ph.D. Senior Vice-President, Head of Sales and Marketing for Roche Applied Science, Germany New paths for treatment of complex diseases: target combinatorial drug therapy Several types of diseases show a complex pathogenesis and require targeted as well as
Aug 13 @ 5:28 pm – 6:03 pm
Invited Talk: Changing landscapes of Biosimilars @ Acharya Hall | Vallikavu | Kerala | India
Rustom Mody, Ph.D. Head R & D Lupin Ltd., Pune Biosimilars are follow-on biologics also known as Similar Biologics – terms used to describe officially approved subsequent versions of innovator biopharmaceutical products made by rDNA technology when made by a
Invited Talk: Translational Biotechnology in the development of Drugs, Diagnostics and Devices @ Acharya Hall | Vallikavu | Kerala | India
Srinivas Pentyala, Ph.D. Director of Translational Research, Faculty member in Anesthesiology, Urology, Health Sciences, Physiology & Biophysics, Stony Brook Medical Center, Stony Brook, NY, USA Translational Biotechnology in the development of Drugs, Diagnostics and Devices Innovation can propel a simple
Delegate Talk: Inefficient NETosis: Cause for Predisposition to Recurrent Infections in Type 2 Diabetes @ Acharya Hall | Vallikavu | Kerala | India
Manjunath Joshi, Apoorva Lad, Bharat Prasad Alevoor, Aswath Balakrishnan, Lingadakai Ramachandra and Kapaettu Satyamoorthy   Pathological conditions during Type 2 Diabetes (T2D) are associated with elevated risk for common community acquired infections due to poor glycemic control. Multiple studies have